Drug Information
Drug General Information | Top | |||
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Drug ID |
D0KH8S
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Former ID |
DNC007241
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Drug Name |
3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzoic acid
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Synonyms |
CHEMBL222180; 3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzoic acid; SCHEMBL13435565
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C16H15NO5
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Canonical SMILES |
C1COCCN1C2=CC(=O)C=C(O2)C3=CC(=CC=C3)C(=O)O
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InChI |
1S/C16H15NO5/c18-13-9-14(11-2-1-3-12(8-11)16(19)20)22-15(10-13)17-4-6-21-7-5-17/h1-3,8-10H,4-7H2,(H,19,20)
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InChIKey |
DIBMCWVULMJJDM-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [1] |
KEGG Pathway | Non-homologous end-joining | |||
Cell cycle | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
Coregulation of Androgen receptor activity | ||||
Class I PI3K signaling events mediated by Akt | ||||
BARD1 signaling events | ||||
Reactome | Nonhomologous End-Joining (NHEJ) | |||
WikiPathways | DNA Damage Response | |||
Non-homologous end joining | ||||
FAS pathway and Stress induction of HSP regulation | ||||
Cytosolic sensors of pathogen-associated DNA | ||||
Retinoblastoma (RB) in Cancer | ||||
Prostate Cancer | ||||
Double-Strand Break Repair | ||||
Cell Cycle | ||||
miRNA Regulation of DNA Damage Response |
References | Top | |||
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REF 1 | Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. |
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