Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0K9OL
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| Former ID |
DNC001306
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| Drug Name |
SCH 50911
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| Synonyms |
SCH 50911; 160415-07-6; UNII-13OB0KEU61; 733717-87-8; 13OB0KEU61; SCH50911; (2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid; SCH-50911; NCGC00024915-02; [(2s)-5,5-Dimethylmorpholin-2-Yl]acetic Acid; DSSTox_RID_81045; DSSTox_CID_25670; DSSTox_GSID_45670; 2-[(2S)-5,5-dimethylmorpholin-2-yl]acetic acid; SCH-50911 free base; CAS-160415-07-6; Spectrum_001764; SCH 50911 free base; AC1NSKM9; Biomol-NT_000243; 2-Morpholineacetic acid, 5,5-dimethyl-, (2S)-; KBioSS_002245; SCHEMBL340881; BPBio1_000749; GTPL1075; ZINC6164; CHEMBL1895916
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| Drug Type |
Small molecular drug
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| Indication | Absence seizure [ICD-11: 8A68.2] | Terminated | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H15NO3
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| Canonical SMILES |
CC1(COC(CN1)CC(=O)O)C
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| InChI |
1S/C8H15NO3/c1-8(2)5-12-6(4-9-8)3-7(10)11/h6,9H,3-5H2,1-2H3,(H,10,11)/t6-/m0/s1
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| InChIKey |
SEYCKMQSPUVYEF-LURJTMIESA-N
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| CAS Number |
CAS 733717-87-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7980582, 11056500, 11364658, 11367220, 11369782, 11377945, 11495578, 26752005, 39341105, 48317615, 48317616, 57359478, 79366857, 92729839, 114156073, 124886959, 132564022, 134339369, 134340510, 135651028, 142796845, 144204487, 162110891, 162223705, 163060180, 163642568, 164133278, 164843410, 170466891, 170475224, 176224841, 189614597, 198970167, 223519243, 226676213, 241182030, 243856372
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Antagonist | [3] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| GABAergic synapse | ||||
| Estrogen signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | Activation of G protein gated Potassium channels | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Potassium Channels | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1075). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005684) | |||
| REF 3 | Activation of nigral dopamine neurons by the selective GABA(B)-receptor antagonist SCH 50911. J Neural Transm. 1999;106(5-6):383-94. | |||
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