Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0K7TX
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| Former ID |
DIB000019
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| Drug Name |
HOE-065
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| Synonyms |
2-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2-azabicyclo[3.3.0]octane-3-carboxylic acid n-octyl ester maleate
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| Drug Type |
Small molecular drug
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| Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7] | Discontinued in Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C35H52N2O9
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| Canonical SMILES |
CCCCCCCCOC(=O)C1CC2CCCC2N1C(=O)C(C)NC(CCC3=CC=CC=C3)C(=O)OCC.C(=CC(=O)O)C(=O)O
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| InChI |
1S/C31H48N2O5.C4H4O4/c1-4-6-7-8-9-13-21-38-31(36)28-22-25-17-14-18-27(25)33(28)29(34)23(3)32-26(30(35)37-5-2)20-19-24-15-11-10-12-16-24;5-3(6)1-2-4(7)8/h10-12,15-16,23,25-28,32H,4-9,13-14,17-22H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t23-,25-,26-,27-,28-;/m0./s1
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| InChIKey |
RCEDCOCCCMIKCY-ZVCJTHDASA-N
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| CAS Number |
CAS 123060-44-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acetylcholine release (Ach rele) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006815) | |||
| REF 2 | Effects of the novel compound, Hoe 065, upon impaired learning and memory in rodents. Eur J Pharmacol. 1989 Nov 14;171(1):79-85. | |||
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