Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0K1VV
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| Former ID |
DIB020983
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| Drug Name |
SR8278
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| Synonyms |
SR 8278; SR-8278
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| Drug Type |
Small molecular drug
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| Indication | Myocardial disease [ICD-11: BC43.20; ICD-10: I42.3, I42.4] | Preclinical | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C18H19NO3S2
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| Canonical SMILES |
CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC
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| InChI |
1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3
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| InChIKey |
UIEBLUZPSFAFOC-UHFFFAOYSA-N
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| CAS Number |
CAS 1254944-66-5
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | V-erbA-related protein 1 (NR1D1) | Target Info | Antagonist | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307. | |||
| REF 2 | Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem Biol. 2011 Feb 18;6(2):131-4. | |||
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