Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0K0WA
|
|||
| Former ID |
DIB004441
|
|||
| Drug Name |
CNTO-5825
|
|||
| Drug Type |
Antibody
|
|||
| Indication | Allergic asthma [ICD-11: CA23.0; ICD-10: J45.0] | Phase 1 | [1] | |
| Company |
Janssen Biotech
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin-13 (IL13) | Target Info | . | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Jak-STAT signaling pathway | ||||
| Fc epsilon RI signaling pathway | ||||
| Measles | ||||
| Asthma | ||||
| Inflammatory bowel disease (IBD) | ||||
| NetPath Pathway | IL9 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| Leptin Signaling Pathway | ||||
| TSLP Signaling Pathway | ||||
| Panther Pathway | Interleukin signaling pathway | |||
| Pathwhiz Pathway | Fc Epsilon Receptor I Signaling in Mast Cells | |||
| Pathway Interaction Database | Glucocorticoid receptor regulatory network | |||
| IL12 signaling mediated by STAT4 | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Cytokines and Inflammatory Response | ||||
| Allograft Rejection | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01081691) A Study Evaluating Intravenous and Subcutaneous Administration of a Human Monoclonal Antibody (CNTO 5825) in Healthy Volunteers. U.S. National Institutes of Health. | |||
| REF 2 | Safety, tolerability and pharmacokinetics of a human anti-interleukin-13 monoclonal antibody (CNTO 5825) in an ascending single-dose first-in-human study. Br J Clin Pharmacol. 2013 May;75(5):1289-98. | |||
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