Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0JY3V
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| Former ID |
DIB012341
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| Drug Name |
Racecadotril
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| Synonyms |
Acetorphan; Hidrasec; Tiorfan
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| Drug Type |
Small molecular drug
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| Indication | Diarrhea [ICD-11: ME05.1; ICD-9: 787.91] | Approved | [1], [2] | |
| Company |
BioProjet; Societe Civile de Recherche
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H23NO4S
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| Canonical SMILES |
CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC2=CC=CC=C2
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| InChI |
1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)
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| InChIKey |
ODUOJXZPIYUATO-UHFFFAOYSA-N
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| CAS Number |
CAS 81110-73-8
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:91508
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -9.039; p = 0.033). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -9.801; p = 0.029). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -9.027; p = 0.05). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -9.427; p = 0.01). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -8.715; p = 0.011). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -8.312; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -7.694; p = 0.022). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -9.333; p = 0.018). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -7.706; p = 0.02). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -5.426; p = 0.007). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -9.556; p = 0.015). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -6.289; p = 0.033). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -5.664; p = 0.009). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -6.728; p = 0.014). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -7.386; p = 0.027). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -6.933; p = 0.013). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -6.066; p = 0.034). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -8.567; p = 0.008). | |||
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Studied Microbe: Bacteroides WH2
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides WH2 (log2FC = -6.566; p = 0.009). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -8.515; p = 0.018). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Odoribacter splanchnicus (log2FC = -5.612; p = 0.034). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -9.672; p = 0.013). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -5.804; p = 0.034). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -6.55; p = 0.033). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Pretovella copri DSM 18205 (log2FC = -7.684; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis ATCC 15703
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bifidobacterium adolescentis ATCC 15703 (log2FC = -1.071; p = 0.006). | |||
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Studied Microbe: Bifidobacterium breve DSM 20213
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -0.679; p = 0.047). | |||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -2.066; p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -3.664; p = 0.029). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Blautia hansenii DSM20583 (log2FC = -9.164; p = 0.029). | |||
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Studied Microbe: Bryantia formatexigens DSM 14469
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -0.815; p = 0.008). | |||
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Studied Microbe: Clostridium difficile 120
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Clostridium difficile 120 (log2FC = -7.853; p = 0.019). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -0.715; p = 0.02). | |||
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Studied Microbe: Clostridium sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Clostridium sp. (log2FC = -8.959; p = 0.026). | |||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -0.885; p = 0.039). | |||
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Studied Microbe: Eubacterium ventriosum ATCC 27560
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -0.483; p = 0.034). | |||
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Studied Microbe: Roseburia intestinalis L1-82
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Roseburia intestinalis L1-82 (log2FC = -0.443; p = 0.034). | |||
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Studied Microbe: Ruminococcus lactaris ATCC 29176
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -1.837; p = 0.037). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -0.527; p = 0.006). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Racecadotril can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -8.23; p = 0.013). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Endopeptidase (ENP) | Target Info | Modulator | [1], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | ClinicalTrials.gov (NCT01577043) Efficacy of Racecadotril in Acute Watery Diarrhea in Children. U.S. National Institutes of Health. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor racecadotril. Front Pharmacol. 2012 May 30;3:93. | |||
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