Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0JY2I
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| Drug Name |
Pyrrolidine derivative 7
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| Synonyms |
PMID25828189-Compound-26
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| Drug Type |
Small molecular drug
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| Company |
SCHERING CORPORATION GILBERT, Eric, J. MILLER, Michael, W. DEMONG, Duane Eugene STAMFORD, Andrew, W. GREENLEE, William, J
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| Structure |
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Download2D MOL |
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| Formula |
C33H32Cl2N2O4
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| Canonical SMILES |
CC(C1=CC=C(C=C1)C(=O)NCCC(=O)O)N2CC(CC2C3=CC4=C(C=C3)C=C(C=C4)OC)C5=CC(=CC(=C5)Cl)Cl
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| InChI |
1S/C33H32Cl2N2O4/c1-20(21-3-5-22(6-4-21)33(40)36-12-11-32(38)39)37-19-27(26-14-28(34)18-29(35)15-26)17-31(37)25-8-7-24-16-30(41-2)10-9-23(24)13-25/h3-10,13-16,18,20,27,31H,11-12,17,19H2,1-2H3,(H,36,40)(H,38,39)/t20?,27-,31-/m1/s1
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| InChIKey |
MKGXNUKACRIFNF-JOPCKLHNSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
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