Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0JI2E
|
|||
| Former ID |
DIB001642
|
|||
| Drug Name |
Aleplasinin
|
|||
| Synonyms |
PAZ-417; PAI inhibitors (Alzheimers disease), Wyeth; Plasminogen activator inhibitor inhibitors (Alzheimers disease),Wyeth
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 1 | [1] | |
| Company |
Wyeth
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C28H27NO3
|
|||
| Canonical SMILES |
CC1=CC(=CC=C1)C2=CC3=C(C=C2)N(C=C3C(=O)C(=O)O)CC4=CC=C(C=C4)C(C)(C)C
|
|||
| InChI |
1S/C28H27NO3/c1-18-6-5-7-20(14-18)21-10-13-25-23(15-21)24(26(30)27(31)32)17-29(25)16-19-8-11-22(12-9-19)28(2,3)4/h5-15,17H,16H2,1-4H3,(H,31,32)
|
|||
| InChIKey |
HSXLMAFNWCSZGP-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 481629-87-2
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasminogen activator inhibitor (PAI) | Target Info | Inhibitor | [2] |
| KEGG Pathway | HIF-1 signaling pathway | |||
| p53 signaling pathway | ||||
| Hippo signaling pathway | ||||
| Complement and coagulation cascades | ||||
| Chagas disease (American trypanosomiasis) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00739037) Study Evaluating PAZ-417 in Cerebrospinal Fluid in Subjects With Alzheimer's Disease. U.S. National Institutes of Health. | |||
| REF 2 | CN patent application no. 102046168, Pai-1 expression and activity inhibitors for the treatment of ocular disorders. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.