Drug Information
Drug General Information | Top | |||
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Drug ID |
D0JF8D
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Former ID |
DNC005910
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Drug Name |
N-(tert-butoxycarbonyl)-tyrosyl-glycine-nitrile
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Synonyms |
dipeptide-derived nitrile, 23; CHEMBL371893; BDBM20102; tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-(4-hydroxyphenyl)ethyl]carbamate
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C16H21N3O4
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Canonical SMILES |
CC(C)(C)OC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NCC#N
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InChI |
1S/C16H21N3O4/c1-16(2,3)23-15(22)19-13(14(21)18-9-8-17)10-11-4-6-12(20)7-5-11/h4-7,13,20H,9-10H2,1-3H3,(H,18,21)(H,19,22)/t13-/m0/s1
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InChIKey |
ZMDCVKGQECBOGN-ZDUSSCGKSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Cathepsin L (CTSL) | Target Info | Inhibitor | [1] |
Cathepsin S (CTSS) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Lysosome | |||
Phagosome | ||||
Antigen processing and presentation | ||||
Proteoglycans in cancer | ||||
Rheumatoid arthritis | ||||
Tuberculosis | ||||
NetPath Pathway | IL4 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
Leptin Signaling Pathway | ||||
IL2 Signaling Pathway | ||||
Reactome | Endosomal/Vacuolar pathway | |||
Collagen degradation | ||||
Degradation of the extracellular matrix | ||||
Trafficking and processing of endosomal TLR | ||||
Assembly of collagen fibrils and other multimeric structures | ||||
MHC class II antigen presentation | ||||
WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | |||
Class I MHC mediated antigen processing & presentation | ||||
Trafficking and processing of endosomal TLR |
References | Top | |||
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REF 1 | Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. |
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