Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0JC9N
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| Former ID |
DAP000115
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| Drug Name |
Adapalene
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| Synonyms |
Adaferin; Adapaleno; Adapalenum; Differin; Differine; CD 271; CD271; Adaferin (TN); Adapaleno [INN-Spanish]; Adapalenum [INN-Latin]; CD-271; Differin (TN); Differin, Adapalene; KS-1196; Adapalene [USAN:BAN:INN]; Adapalene (JAN/USAN/INN); 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid; 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid; 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid; 6-[3-(adamantan-1-yl)-4-methoxyphenyl]-2-naphthoic acid
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| Drug Type |
Small molecular drug
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| Indication | Acne vulgaris [ICD-11: ED80; ICD-10: L70.0; ICD-9: 706.1] | Approved | [1], [2] | |
| Therapeutic Class |
Dermatologic Agents
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| Company |
Galderma Laboratories
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| Structure |
 |
Download2D MOL |
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| Formula |
C28H28O3
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| Canonical SMILES |
COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5
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| InChI |
1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)
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| InChIKey |
LZCDAPDGXCYOEH-UHFFFAOYSA-N
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| CAS Number |
CAS 106685-40-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6822615, 7848175, 8186698, 14757761, 15676959, 26719856, 26758039, 43117595, 46386720, 46505019, 49830264, 50064121, 56394856, 57313991, 80928761, 85174389, 92712347, 93166422, 93815151, 99300517, 99437066, 103390862, 103978806, 104131655, 104320030, 109693041, 117546878, 119525345, 121362199, 124757134, 124893173, 125163938, 125333636, 125536425, 126630117, 126656770, 126666780, 128562074, 131293846, 134337439, 134358633, 135018958, 135653634, 135692088, 135696673, 136375522, 137003094, 142336877, 144115539, 144205789
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| ChEBI ID |
CHEBI:31174
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| ADReCS Drug ID | BADD_D00042 | |||
| SuperDrug ATC ID |
D10AD03
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| SuperDrug CAS ID |
cas=106685409
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Retinoic acid receptor (RAR) | Target Info | Binder | [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5429). | |||
| REF 2 | Topical retinoids in acne vulgaris: update on efficacy and safety. Am J Clin Dermatol. 2008;9(6):369-81. | |||
| REF 3 | A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008 Nov;43(5):421-4. | |||
| REF 4 | Topical treatment in acne: current status and future aspects. Dermatology. 2003;206(1):29-36. | |||
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