Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0JA5D
|
|||
| Former ID |
DIB020834
|
|||
| Drug Name |
RO330-0802/001
|
|||
| Synonyms |
RO330-0802/001; GTPL792; SCHEMBL1223935
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C27H30Cl2N4O3S
|
|||
| Canonical SMILES |
COC1=C(C=C(C=C1)C2=CN=C(N=C2)SCC(=O)NCCC3CC(CN3)CC4=CC(=C(C=C4)Cl)Cl)OC
|
|||
| InChI |
1S/C27H30Cl2N4O3S/c1-35-24-6-4-19(12-25(24)36-2)20-14-32-27(33-15-20)37-16-26(34)30-8-7-21-10-18(13-31-21)9-17-3-5-22(28)23(29)11-17/h3-6,11-12,14-15,18,21,31H,7-10,13,16H2,1-2H3,(H,30,34)/t18-,21-/m1/s1
|
|||
| InChIKey |
OPLAETMHSJFRBS-WIYYLYMNSA-N
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CCR3 messenger RNA (CCR3 mRNA) | Target Info | Antagonist | [2] |
| NetPath Pathway | IL3 Signaling Pathway | |||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 792). | |||
| REF 2 | Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1602-9. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.