Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J8WJ
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| Former ID |
DIB003107
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| Drug Name |
AKL-0707
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| Synonyms |
Akela GHRH; LAB GHRH; GHRH analog, Akela; Malnutrition therapy, LAB International
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| Indication | Lipodystrophy [ICD-11: EF01; ICD-10: E88.1; ICD-9: 272.6] | Discontinued in Phase 2 | [1] | |
| Company |
Akela Pharma Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Growth hormone-releasing hormone receptor (GHRHR) | Target Info | Agonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | G alpha (s) signalling events | |||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021539) | |||
| REF 2 | A super-agonist of growth hormone-releasing hormone causes rapid improvement of nutritional status in patients with chronic kidney disease. Kidney Int. 2010 Mar;77(5):450-8. | |||
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