Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0J3PJ
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| Former ID |
DIB020916
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| Drug Name |
SB-408124
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| Synonyms |
SB 408124; SB408124
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C19H18F2N4O
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| Canonical SMILES |
CC1=CC(=C2C=C(C=C(C2=N1)F)F)NC(=O)NC3=CC=C(C=C3)N(C)C
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| InChI |
1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26)
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| InChIKey |
JTARFZSNUAGHRB-UHFFFAOYSA-N
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| CAS Number |
CAS 288150-92-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6367930, 9643540, 11114251, 15447767, 29215048, 35632985, 57356933, 74849423, 99437200, 112842211, 128323484, 134437896, 135651007, 135698518, 136348249, 136367544, 136367785, 137010140, 143038485, 152258894, 152344307, 160647742, 162023370, 162038055, 162403564, 163180658, 164152523, 177748538, 179336944, 185990419, 188919877, 223395551, 223496595, 223705249, 227781286, 241056544, 241375714, 251963243, 252125396, 252156219, 252216265, 252447316, 252473357
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| ChEBI ID |
CHEBI:92941
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Orexin receptor type 1 (HCRTR1) | Target Info | Antagonist | [2] |
| Orexin receptor type 2 (HCRTR2) | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1704). | |||
| REF 2 | Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison ... Mol Pharmacol. 2009 Sep;76(3):618-31. | |||
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