Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0IT9C
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| Drug Name |
Picolinamido propanoic acid derivative 1
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| Synonyms |
PMID25828189-Compound-10
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| Drug Type |
Small molecular drug
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| Company |
JANSSEN PHARMACEUTICA NV CHAKRAVARTY, Devraj KREUTTER, Kevin POWELL, Mark SHOOK, Brian SONG, Fengbin XU, Guozhang YANG, Shyh-ming ZHANG, Rui ZHAO, Bao-pin
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| Structure |
 |
Download2D MOL |
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| Formula |
C31H24ClF6N3O3
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| Canonical SMILES |
CC1=C(C=CC(=C1)C(F)(F)F)C2=C(C=C(C=C2)NCC3=C(C=C(C=C3)C(F)(F)F)C4=CN=C(C=C4)C(=O)NCCC(=O)O)Cl
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| InChI |
1S/C31H24ClF6N3O3/c1-17-12-20(30(33,34)35)5-7-23(17)24-8-6-22(14-26(24)32)40-15-18-2-4-21(31(36,37)38)13-25(18)19-3-9-27(41-16-19)29(44)39-11-10-28(42)43/h2-9,12-14,16,40H,10-11,15H2,1H3,(H,39,44)(H,42,43)
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| InChIKey |
GPKUFXAKPUJEDG-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
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