Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0IL0U
|
|||
| Drug Name |
Heterocycle-containing compound 4
|
|||
| Synonyms |
PMID25828189-Compound-16
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Company |
PFIZER INC. ASPNES, Gary, Erik DIDIUK, Mary, Theresa FILIPSKI, Kevin, James GUZMAN-PEREZ, Angel PFEFFERKORN, Jeffrey, Allen STEVENS, Benjamin, Dawson TU, Meihua, Mik
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C26H27F3N4O3
|
|||
| Canonical SMILES |
CC(C)CC(C1=CC=C(C=C1)C2=NC=C(C=C2)C(F)(F)F)NC3=NC=C(C=C3)C(=O)NCCC(=O)O
|
|||
| InChI |
1S/C26H27F3N4O3/c1-16(2)13-22(33-23-10-7-19(14-32-23)25(36)30-12-11-24(34)35)18-5-3-17(4-6-18)21-9-8-20(15-31-21)26(27,28)29/h3-10,14-16,22H,11-13H2,1-2H3,(H,30,36)(H,32,33)(H,34,35)/t22-/m0/s1
|
|||
| InChIKey |
MSWXTYSARYGQHP-QFIPXVFZSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.