Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0IF3N
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| Former ID |
DIB020467
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| Drug Name |
N,N-dimethylhistamine
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| Synonyms |
N,N-Dimethylhistamine; 4-(2-Dimethylaminoethyl)imidazole; SU-416; Na,Na-Dimethylhistamine; 673-46-1; N(sup alpha),N(sup alpha)-Dimethylhistamine; N',N'-Dimethylhistamine; [2-(1H-imidazol-4-yl)ethyl]dimethylamine; 1H-Imidazole-4-ethanamine, N,N-dimethyl-; Imidazole, 4-[2-(dimethylamino)ethyl]-; IMIDAZOLE, 4-(2-(DIMETHYLAMINO)ETHYL)-; 4-[2-(Dimethylamino)ethyl]-Imidazole; 4-(2-(Dimethylamino)ethyl)-Imidazole; Hippospongine ; N-dimethylhistamine; CHEMBL12704; Nalpha,Nalpha-Dimethylhistamine; SCHEMBL1239352; AC1L202F; GTPL1270
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C7H13N3
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| Canonical SMILES |
CN(C)CCC1=CN=CN1
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| InChI |
1S/C7H13N3/c1-10(2)4-3-7-5-8-6-9-7/h5-6H,3-4H2,1-2H3,(H,8,9)
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| InChIKey |
ZJDIMSMQXMWMCF-UHFFFAOYSA-N
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| CAS Number |
CAS 673-46-1
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H4 receptor (H4R) | Target Info | Agonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCR ligand binding | |||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1270). | |||
| REF 2 | Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br J Pharmacol. 2006 Apr;147(7):744-54. | |||
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