Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0I8CA
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| Former ID |
DAP001485
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| Drug Name |
Isoxyl
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| Synonyms |
Tiocarlide; Thiocarlide; Tiocarlid; 910-86-1; Disocarban; Datanil; Tiocarlidum [INN-Latin]; Tiocarlida [INN-Spanish]; 4,4'-Diisoamyloxythiocarbanilide; 4,4'-Bis(isopentyloxy)thiocarbanilide; Tiocarlide [INN:BAN:DCF]; UNII-43M23X81Y2; C23H32N2O2S; N,N'-Bis(4-(3-methylbutoxy)phenyl)thiourea; EINECS 213-006-5; CARBANILIDE, 4,4'-BIS(ISOPENTYLOXY)THIO-; BRN 2546347; Thiourea, N,N'-bis[4-(3-methylbutoxy)phenyl]-; Thiourea, N,N'-bis(4-(3-methylbutoxy)phenyl)-; NSC742400; 43M23X81Y2; Amixyl; Disoxyl; Tiocarlida; Tiocarlidum; BRN2546347; Tiocarlide (INN); Tiocarlide [INN:DCF]; Thiourea, N,N'-bis(4-(3-methylbutoxy)phenyl)-(9CI)
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C23H32N2O2S
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| Canonical SMILES |
CC(C)CCOC1=CC=C(C=C1)NC(=S)NC2=CC=C(C=C2)OCCC(C)C
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| InChI |
1S/C23H32N2O2S/c1-17(2)13-15-26-21-9-5-19(6-10-21)24-23(28)25-20-7-11-22(12-8-20)27-16-14-18(3)4/h5-12,17-18H,13-16H2,1-4H3,(H2,24,25,28)
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| InChIKey |
BWBONKHPVHMQHE-UHFFFAOYSA-N
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| CAS Number |
CAS 910-86-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
618324, 10036574, 14854759, 34667213, 49901498, 51091584, 57410144, 71840378, 80118270, 91146578, 103500156, 111610929, 125335141, 127576462, 134338677, 134340615, 134979731, 136357895, 137006685, 138323082, 164788702, 179226149, 184546012, 198971104, 223704993, 226666634, 241164677, 249979870, 252351068, 252457797, 252467832
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| ChEBI ID |
CHEBI:135637
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| SuperDrug ATC ID |
J04AD02
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| SuperDrug CAS ID |
cas=000910861
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acyl-CoA desaturase (SCD) | Target Info | Binder | [1], [2] |
| KEGG Pathway | Metabolic pathways | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92. | |||
| REF 2 | Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis. J Biol Chem. 2003 Dec 26;278(52):53123-30. | |||
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