Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0I7TN
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| Former ID |
DIB011183
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| Drug Name |
3-DEAZAADENOSINE
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| Synonyms |
Cc3Ado; BW-91Y78; 3DZA; 4-Amino-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridine
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| Drug Type |
Small molecular drug
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| Indication | Arthritis [ICD-11: FA20] | Terminated | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H14N4O4
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| Canonical SMILES |
C1=CN=C(C2=C1N(C=N2)C3C(C(C(O3)CO)O)O)N
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| InChI |
1S/C11H14N4O4/c12-10-7-5(1-2-13-10)15(4-14-7)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
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| InChIKey |
DBZQFUNLCALWDY-PNHWDRBUSA-N
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| CAS Number |
CAS 6736-58-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
599355, 822005, 831488, 7885704, 8166952, 14872495, 14872496, 24278391, 29290367, 46392142, 53776887, 53787334, 56312471, 57331322, 80626742, 81060187, 91703946, 93166861, 103482215, 104357832, 127712622, 131342629, 134987351, 143236490, 162249371, 163129942, 164838859, 172911459, 178101808, 184587808, 198988279, 219814882, 223579627, 223692121, 227919516, 249853649, 250220991, 252071801, 252413831
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | AdoHcy hydrolase (SAHase) | Target Info | Modulator | [3] |
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5115). | |||
| REF 2 | Pharmacokinetics of the antiviral agent carbocyclic 3-deazaadenosine. Drug Metab Dispos. 1993 Jul-Aug;21(4):555-9. | |||
| REF 3 | Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem. 2003 Sep;270(17):3507-17. | |||
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