Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0I7BU
|
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| Former ID |
DCL000410
|
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| Drug Name |
GSK1482160
|
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| Indication | Pain [ICD-11: MG30-MG3Z] | Phase 1 | [1] | |
| Therapeutic Class |
Analgesics
|
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| Company |
GSK
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C14H14ClF3N2O2
|
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| Canonical SMILES |
CN1C(CCC1=O)C(=O)NCC2=C(C(=CC=C2)C(F)(F)F)Cl
|
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| InChI |
1S/C14H14ClF3N2O2/c1-20-10(5-6-11(20)21)13(22)19-7-8-3-2-4-9(12(8)15)14(16,17)18/h2-4,10H,5-7H2,1H3,(H,19,22)
|
|||
| InChIKey |
BJEMSIVBBUBXMZ-UHFFFAOYSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P2X purinoceptor 7 (P2RX7) | Target Info | Antagonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Reactome | The NLRP3 inflammasome | |||
| WikiPathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029786) | |||
| REF 2 | Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). | |||
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