Drug Information
Drug General Information | Top | |||
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Drug ID |
D0I6UM
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Former ID |
DNC010238
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Drug Name |
NSC-745885
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Synonyms |
NSC-745885; AC1MYPDK; SCHEMBL1217478; CHEMBL594366; SJPXIVLTCBBWKT-UHFFFAOYSA-N; MolPort-002-321-063; ZINC4016501; STK368283; NSC745885; AKOS005445050; MCULE-4713643178; ST50889307; anthra[1,2-c]1,2,5-thiadiazole-6,11-dione; anthra[1,2-c][1,2,5]thiadiazole-6,11-dione; anthra [1,2-c]-1,2,5-thiadiazole-6,11-dione
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C14H6N2O2S
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Canonical SMILES |
C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C4=NSN=C4C=C3
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InChI |
1S/C14H6N2O2S/c17-13-7-3-1-2-4-8(7)14(18)11-9(13)5-6-10-12(11)16-19-15-10/h1-6H
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InChIKey |
SJPXIVLTCBBWKT-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | TERT messenger RNA (TERT mRNA) | Target Info | Inhibitor | [1] |
KEGG Pathway | HTLV-I infection | |||
NetPath Pathway | IL2 Signaling Pathway | |||
Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
Regulation of Telomerase | ||||
IL2 signaling events mediated by PI3K | ||||
Regulation of nuclear beta catenin signaling and target gene transcription | ||||
HIF-1-alpha transcription factor network | ||||
Reactome | Formation of the beta-catenin:TCF transactivating complex | |||
WikiPathways | TGF beta Signaling Pathway | |||
miR-targeted genes in lymphocytes - TarBase | ||||
miR-targeted genes in epithelium - TarBase | ||||
Telomere Maintenance |
References | Top | |||
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REF 1 | Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. |
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