Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0I1OS
|
|||
Former ID |
DIB009977
|
|||
Drug Name |
E-2212
|
|||
Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 1 | [1] | |
Company |
Eisai Co Ltd
|
|||
Structure |
Download2D MOL |
|||
Formula |
C25H23F3N6O
|
|||
Canonical SMILES |
CC1=CN(C=N1)C2=C(N=C(C=C2)C=CC3=NN4CCCC(C4=N3)C5=CC=CC=C5C(F)(F)F)OC
|
|||
InChI |
1S/C25H23F3N6O/c1-16-14-33(15-29-16)21-11-9-17(30-24(21)35-2)10-12-22-31-23-19(7-5-13-34(23)32-22)18-6-3-4-8-20(18)25(26,27)28/h3-4,6,8-12,14-15,19H,5,7,13H2,1-2H3/b12-10+/t19-/m0/s1
|
|||
InChIKey |
SSGLBUGNISHUAO-RDELFYGPSA-N
|
|||
CAS Number |
CAS 1123193-82-7
|
|||
PubChem Compound ID |
References | Top | |||
---|---|---|---|---|
REF 1 | ClinicalTrials.gov (NCT01221259) A Randomized, Double-blind, Placebo-controlled, Sequential Ascending, Single-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2212 in Healthy Subjects. U.S. National Institutes of Health. | |||
REF 2 | Development and mechanism of gamma-secretase modulators for Alzheimer's disease. Biochemistry. 2013 May 14;52(19):3197-216. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.