Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0HV7T
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| Drug Name |
Picolinamido propanoic acid derivative 3
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| Synonyms |
PMID25828189-Compound-12
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| Drug Type |
Small molecular drug
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| Company |
JANSSEN PHARMACEUTICA NV CHAKRAVARTY, Devraj KREUTTER, Kevin POWELL, Mark SHOOK, Brian SONG, Fengbin XU, Guozhang YANG, Shyh-ming ZHANG, Rui ZHAO, Bao-pin
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| Structure |
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Download2D MOL |
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| Formula |
C30H23ClF3N3O4
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| Canonical SMILES |
CC1=C(C=CC(=C1)Cl)C2=CC=C(C=C2)NC(=O)C3=C(C=C(C=C3)C(F)(F)F)C4=CN=C(C=C4)C(=O)NCCC(=O)O
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| InChI |
1S/C30H23ClF3N3O4/c1-17-14-21(31)6-10-23(17)18-2-7-22(8-3-18)37-28(40)24-9-5-20(30(32,33)34)15-25(24)19-4-11-26(36-16-19)29(41)35-13-12-27(38)39/h2-11,14-16H,12-13H2,1H3,(H,35,41)(H,37,40)(H,38,39)
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| InChIKey |
QISSKZBXYOVUJU-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
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