Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0HL1X
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| Former ID |
DIB014878
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| Drug Name |
ISIS-PKK
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| Synonyms |
ISIS-PKKRx
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| Drug Type |
Antisense drug
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| Indication | Amyloid cardiomyopathy [ICD-11: 5D00.20; ICD-10: E85.1] | Phase 3 | [1] | |
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasma kallikrein messenger RNA (KLKB1 mRNA) | Target Info | . | [2] |
| KEGG Pathway | Complement and coagulation cascades | |||
| NetPath Pathway | AndrogenReceptor Signaling Pathway | |||
| Panther Pathway | Blood coagulation | |||
| Pathwhiz Pathway | Coagulation | |||
| Reactome | Intrinsic Pathway of Fibrin Clot Formation | |||
| Activation of Matrix Metalloproteinases | ||||
| WikiPathways | Complement and Coagulation Cascades | |||
| Human Complement System | ||||
| Blood Clotting Cascade | ||||
| Formation of Fibrin Clot (Clotting Cascade) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034193) | |||
| REF 2 | Clinical pipeline report, company report or official report of ISIS Pharmaceuticals. | |||
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