Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H5JW
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Former ID |
DIB018213
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Drug Name |
[3H](R)-(-)-baclofen
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Synonyms |
AC1OCG0F; ZB000014
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Drug Type |
Small molecular drug
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Indication | Multiple sclerosis [ICD-11: 8A40] | Phase 3 | [1] | |
Structure |
Download2D MOL |
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Formula |
C10H12ClNO2
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Canonical SMILES |
C1=CC(=CC=C1C(CC(=O)O)CN)Cl
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InChI |
1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/t8-/m0/s1
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InChIKey |
KPYSYYIEGFHWSV-QMMMGPOBSA-N
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CAS Number |
CAS 69308-37-8
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Agonist | [2] |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
GABAergic synapse | ||||
Estrogen signaling pathway | ||||
Morphine addiction | ||||
Reactome | Activation of G protein gated Potassium channels | |||
G alpha (i) signalling events | ||||
Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Potassium Channels | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT02869425) To Assess Effects of Arbaclofen ER Tablets Compared With Placebo on Sperm Parameters in Male Subjects With MS. U.S. National Institutes of Health. | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 242). |
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