Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H5HZ
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Former ID |
DIB007148
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Drug Name |
Etamicastat
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Synonyms |
BIA-5453; Dopamine beta hydroxylase inhibitors (cardiovascular diseases), BIAL; Dopamine beta hydroxylase inhibitors (cardiovascular diseases), Portela
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Drug Type |
Small molecular drug
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Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Phase 2 | [1] | |
Company |
Portela & Ca SA
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Structure |
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Download2D MOL |
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Formula |
C14H15F2N3OS
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Canonical SMILES |
C1C(COC2=C1C=C(C=C2F)F)N3C(=CNC3=S)CCN
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InChI |
1S/C14H15F2N3OS/c15-9-3-8-4-11(7-20-13(8)12(16)5-9)19-10(1-2-17)6-18-14(19)21/h3,5-6,11H,1-2,4,7,17H2,(H,18,21)/t11-/m1/s1
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InChIKey |
CWWWTTYMUOYSQA-LLVKDONJSA-N
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CAS Number |
CAS 760173-05-5
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Dopamine beta hydroxylase (DBH) | Target Info | Inhibitor | [2] |
BioCyc | Catecholamine biosynthesis | |||
KEGG Pathway | Tyrosine metabolism | |||
Metabolic pathways | ||||
Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
Dopamine receptor mediated signaling pathway | ||||
Pathwhiz Pathway | Catecholamine Biosynthesis | |||
Tyrosine Metabolism | ||||
WikiPathways | Monoamine Transport | |||
Biogenic Amine Synthesis | ||||
Metabolism of amino acids and derivatives |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034724) | |||
REF 2 | Safety, tolerability, and pharmacokinetics of etamicastat, a novel dopamine-beta-hydroxylase inhibitor, in a rising multiple-dose study in young healthy subjects. Drugs R D. 2010;10(4):225-42. |
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