Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H5BC
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| Former ID |
DIB001016
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| Drug Name |
Tosagestin
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| Synonyms |
Org-30659; Org-30659/estradiol
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| Drug Type |
Small molecular drug
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| Indication | Contraception [ICD-11: QA21] | Phase 2 | [1] | |
| Company |
Organon BioSciences
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H24O2
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| Canonical SMILES |
CC12CC(=C)C3C(C1C=CC2(C#C)O)CCC4=CC(=O)CCC34
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| InChI |
1S/C21H24O2/c1-4-21(23)10-9-18-17-7-5-14-11-15(22)6-8-16(14)19(17)13(2)12-20(18,21)3/h1,9-11,16-19,23H,2,5-8,12H2,3H3/t16-,17-,18-,19+,20-,21-/m0/s1
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| InChIKey |
YJSTYQGZKJHXLN-OLGWUGKESA-N
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| CAS Number |
CAS 110072-15-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Progesterone receptor (PGR) | Target Info | Agonist | [2] |
| KEGG Pathway | Oocyte meiosis | |||
| Progesterone-mediated oocyte maturation | ||||
| Pathway Interaction Database | Cellular roles of Anthrax toxin | |||
| Reactome | Nuclear signaling by ERBB4 | |||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Ovarian Infertility Genes | |||
| Signaling by ERBB4 | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women. J Steroid Biochem Mol Biol. 2000 May;73(1-2):39-48. | |||
| REF 2 | Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions. J Steroid Biochem Mol Biol. 1992 Jun;42(5):457-65. | |||
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