Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H3YC
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| Former ID |
DIB009861
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| Drug Name |
EP-128504
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| Synonyms |
MX-116839; MX-126374; MX-126911; MX-128504; MX-74420; MX-77356; IGF modulator (cancer), Maxim; IGF-2 receptor modulators (cancer); IGF-2 receptor modulators (cancer), EpiCept; IGF-2 receptor modulators (cancer), Maxim; Insulin-like growth factor modulator (cancer), Maxim
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Preclinical | [1] | |
| Company |
Maxim Pharmaceuticals Inc
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CI Man-6-P receptor (IGF2R) | Target Info | Modulator | [2], [3] |
| KEGG Pathway | Lysosome | |||
| Panther Pathway | Apoptosis signaling pathway | |||
| Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade | ||||
| Insulin/IGF pathway-protein kinase B signaling cascade | ||||
| Reactome | Golgi Associated Vesicle Biogenesis | |||
| WikiPathways | miR-targeted genes in muscle cell - TarBase | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in leukocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| miR-targeted genes in adipocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017941) | |||
| REF 2 | The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach. Mol Cancer Ther. 2005 May;4(5):761-71. | |||
| REF 3 | Cation-independent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-beta1. Am J Physiol Renal Physiol.2011 Jul;301(1):F84-93. | |||
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