Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0H2LT
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| Former ID |
DNC014692
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| Drug Name |
4-Amino-3-(2-chloro-phenyl)-butyric acid
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| Synonyms |
CHEMBL83245; 28311-34-4; 4-Amino-3-(2-chloro-phenyl)-butyric acid; SCHEMBL349398; BDBM50007121; AKOS015157811; 4-Amino-3-(2-chlorophenyl)butyric acid; 4-amino-3-(2-chlorophenyl)butanoic acid; 4-amino-3-(-chlorophenyl)-butanoic acid; Benzenepropanoic acid, beta-(aminomethyl)-2-chloro-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H12ClNO2
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| Canonical SMILES |
C1=CC=C(C(=C1)C(CC(=O)O)CN)Cl
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| InChI |
1S/C10H12ClNO2/c11-9-4-2-1-3-8(9)7(6-12)5-10(13)14/h1-4,7H,5-6,12H2,(H,13,14)
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| InChIKey |
RNSIJRUPQJHCBR-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gamma-aminobutyric acid B receptor (GABBR) | Target Info | Inhibitor | [1] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| GABAergic synapse | ||||
| Estrogen signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | Activation of G protein gated Potassium channels | |||
| G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Potassium Channels | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. J Med Chem. 1991 Aug;34(8):2557-60. | |||
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