Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H1II
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Former ID |
DNC006473
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Drug Name |
1-(3-cyano-1-methyl-1H-indol-6-yl)-3-phenylurea
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Synonyms |
CHEMBL333482; AC1LABSI; 1-(3-cyano-1-methyl-1H-indol-6-yl)-3-phenylurea; BDBM50133727; 1-(3-cyano-1-methylindol-6-yl)-3-phenylurea; 1-(3-Cyano-1-methyl-1H-indol-6-yl)-3-phenyl-urea
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C17H14N4O
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Canonical SMILES |
CN1C=C(C2=C1C=C(C=C2)NC(=O)NC3=CC=CC=C3)C#N
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InChI |
1S/C17H14N4O/c1-21-11-12(10-18)15-8-7-14(9-16(15)21)20-17(22)19-13-5-3-2-4-6-13/h2-9,11H,1H3,(H2,19,20,22)
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InChIKey |
DKHWZIZMXRFFLI-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) | Target Info | Inhibitor | [1] |
BioCyc | Purine nucleotides degradation | |||
Urate biosynthesis/inosine 5'-phosphate degradation | ||||
Guanosine nucleotides de novo biosynthesis | ||||
Superpathway of purine nucleotide salvage | ||||
Purine nucleotides de novo biosynthesis | ||||
Guanosine ribonucleotides de novo biosynthesis | ||||
KEGG Pathway | Purine metabolism | |||
Drug metabolism - other enzymes | ||||
Metabolic pathways | ||||
Panther Pathway | De novo purine biosynthesis | |||
Reactome | Purine ribonucleoside monophosphate biosynthesis |
References | Top | |||
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REF 1 | Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. |
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