Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H1GF
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Former ID |
DIB008205
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Drug Name |
Sch-34826
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Synonyms |
Sch-34826; Sch 34826; 105262-04-2; N-(N-(1-(((2,2-Dimethyl-1,3-dioxolan-4-yl) methoxy)carbonyl)-2-phenylethyl)phenylalanine)alanine; beta-Alanine, N-(N-(2-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2-oxo-1-(phenylmethyl)ethyl)-L-phenylalanyl)-; SCHEMBL489561; AC1L3U54; LS-186875; LS-187530; 3-[[(2S)-2-[[1-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-1-oxo-3-phenylpropan-2-yl]amino]-3-phenylpropanoyl]amino]propanoic acid
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Discontinued in Phase 2 | [1] | |
Company |
Schering-Plough Corp
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Structure |
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Download2D MOL |
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Formula |
C27H34N2O7
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Canonical SMILES |
CC1(OCC(O1)COC(=O)C(CC2=CC=CC=C2)NC(CC3=CC=CC=C3)C(=O)NCCC(=O)O)C
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InChI |
1S/C27H34N2O7/c1-27(2)35-18-21(36-27)17-34-26(33)23(16-20-11-7-4-8-12-20)29-22(15-19-9-5-3-6-10-19)25(32)28-14-13-24(30)31/h3-12,21-23,29H,13-18H2,1-2H3,(H,28,32)(H,30,31)/t21?,22-,23?/m0/s1
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InChIKey |
GWLFRMJMKXSMSR-KOENEWCDSA-N
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CAS Number |
CAS 105262-04-2
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Neutral endopeptidase (MME) | Target Info | Modulator | [2] |
KEGG Pathway | Renin-angiotensin system | |||
Hematopoietic cell lineage | ||||
Protein digestion and absorption | ||||
Alzheimer's disease | ||||
NetPath Pathway | EGFR1 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
WikiPathways | Metabolism of Angiotensinogen to Angiotensins | |||
Primary Focal Segmental Glomerulosclerosis FSGS | ||||
Alzheimers Disease |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000196) | |||
REF 2 | Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic. J Pharmacol Exp Ther. 1988 Jun;245(3):829-38. |
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