Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H0CH
|
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| Drug Name |
PMID30107136-Compound-Example54
|
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| Drug Type |
Small molecule immunotherapy
|
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| Indication | Hepatitis [ICD-11: DB97.Z] | Patented | [1] | |
| Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 42] | Patented | [1] | ||
| Infectious disease [ICD-11: 1A00-CA43.1; ICD-10: A00-B99; ICD-9: 001-139] | Patented | [1] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
| Company |
INCYTE CORPORATION
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C28H28N2O3
|
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| Canonical SMILES |
CC1=CC(=CC2=C1OC(=N2)C3=CC=CC(=C3C)C4=CC=CC=C4)CN5CCCCC5C(=O)O
|
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| InChI |
1S/C28H28N2O3/c1-18-15-20(17-30-14-7-6-13-25(30)28(31)32)16-24-26(18)33-27(29-24)23-12-8-11-22(19(23)2)21-9-4-3-5-10-21/h3-5,8-12,15-16,25H,6-7,13-14,17H2,1-2H3,(H,31,32)/t25-/m0/s1
|
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| InChIKey |
UWWIGOJLOPXCJZ-VWLOTQADSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target Info | Inhibitor | [1] |
| Target's Patent Info | PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target's Patent Info | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. | |||
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