Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0GS9X
|
|||
| Former ID |
DNCL002175
|
|||
| Drug Name |
OMP-21M18
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1], [2], [3] | |
| Company |
GlaxoSmithKline
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Delta-like protein 4 (DLL4) | Target Info | Modulator | [4] |
| KEGG Pathway | Notch signaling pathway | |||
| NetPath Pathway | Notch Signaling Pathway | |||
| Panther Pathway | Angiogenesis | |||
| Notch signaling pathway | ||||
| Pathway Interaction Database | Notch signaling pathway | |||
| Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | |||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
| Constitutive Signaling by NOTCH1 t(7 | ||||
| M1580_K2555) Translocation Mutant | ||||
| Constitutive Signaling by NOTCH1 HD Domain Mutants | ||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
| NOTCH2 Activation and Transmission of Signal to the Nucleus | ||||
| WikiPathways | Notch Signaling Pathway | |||
| Signaling by NOTCH3 | ||||
| Signaling by NOTCH4 | ||||
| Signaling by NOTCH1 | ||||
| Signaling by NOTCH2 | ||||
| Notch Signaling Pathway | ||||
| Neural Crest Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8451). | |||
| REF 2 | ClinicalTrials.gov (NCT00744562) A Phase 1 Dose Escalation Study of OMP-21M18 in Subjects With Solid Tumors. U.S. National Institutes of Health. | |||
| REF 3 | Clinical pipeline report, company report or official report of OncoMed Pharmaceuticals. | |||
| REF 4 | National Cancer Institute Drug Dictionary (drug id 614677). | |||
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