Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0GD8Y
|
|||
| Former ID |
DNC001480
|
|||
| Drug Name |
U0126
|
|||
| Synonyms |
U0126; 109511-58-2; U-0126; U 0126; 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene; UNII-8027P94HLL; CHEBI:64208; 8027P94HLL; (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile; FT-1069-1; 218601-62-8; Succinonitrile, bis(amino(o-aminophenylthio)methylene)-; Butanedinitrile, bis(amino((2-aminophenyl)thio)methylene)-; C18H16N6S2; (2z)-Bis{amino[(2-Aminophenyl)sulfanyl]methylidene}butanedinitrile; (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylene}succinonitrile
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C18H16N6S2
|
|||
| Canonical SMILES |
C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
|
|||
| InChI |
1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
|
|||
| InChIKey |
DVEXZJFMOKTQEZ-JYFOCSDGSA-N
|
|||
| CAS Number |
CAS 218601-62-8
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
813618, 10038395, 14804608, 26752095, 26752096, 36055645, 47588773, 47885188, 47885189, 47959485, 48034856, 50066355, 50104749, 53787417, 56310895, 56311742, 56311899, 57269493, 57410191, 80329815, 85752743, 85788232, 92310148, 99301060, 99302580, 100053924, 104051586, 104234171, 111619826, 123120887, 124658704, 126671648, 135154095, 135610799, 139404187, 152344238, 162189506, 173131127, 177748596, 178101965, 179252618, 184596901, 198952879, 204356986, 223366705, 223654546, 241182169, 241375247, 249820030, 252216541
|
|||
| ChEBI ID |
CHEBI:64208
|
|||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5282). | |||
| REF 2 | Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. | |||
| REF 3 | Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11569-74. | |||
| REF 4 | Transcriptional regulation of basal cyclooxygenase-2 expression in murine lung tumor-derived cell lines by CCAAT/enhancer-binding protein and activating transcription factor/cAMP response element-binding protein. Mol Pharmacol. 2002 Aug;62(2):326-33. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.