Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0G8QW
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| Former ID |
DNAP001470
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| Drug Name |
Delapril
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| Synonyms |
Adecut (TN)
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Cardiovascular disease [ICD-11: BA00-BE2Z; ICD-10: I00-I99] | Approved | [1] | |
| Company |
Takeda
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| Structure |
 |
Download2D MOL |
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| Formula |
C26H32N2O5
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| Canonical SMILES |
CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N(CC(=O)O)C2CC3=CC=CC=C3C2
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| InChI |
1S/C26H32N2O5/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30)/t18-,23-/m0/s1
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| InChIKey |
WOUOLAUOZXOLJQ-MBSDFSHPSA-N
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| CAS Number |
CAS 83435-66-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11654001, 15502898, 39384396, 50065283, 50126306, 50744263, 57362083, 93309517, 96024479, 103724094, 114149701, 126651900, 126684019, 129612377, 135049416, 137246262, 141423284, 142651271, 163133920, 163693521, 163852909, 164788297, 179151266, 184545947, 196110804, 196383754, 198935554, 223682687, 226420640, 252347893
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| ChEBI ID |
CHEBI:135735
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| SuperDrug ATC ID |
C09AA12
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin-converting enzyme (ACE) | Target Info | Modulator | [1], [2], [3], [4] |
| KEGG Pathway | Renin-angiotensin system | |||
| Chagas disease (American trypanosomiasis) | ||||
| Hypertrophic cardiomyopathy (HCM) | ||||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| Metabolism of Angiotensinogen to Angiotensins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Natural products in drug discovery and development. J Nat Prod. 1997 Jan;60(1):52-60. | |||
| REF 3 | The influence of natural products upon drug discovery. Nat Prod Rep. 2000 Jun;17(3):215-34. | |||
| REF 4 | Drug discovery from natural sources. AAPS J. 2006 Apr 14;8(2):E239-53. | |||
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