Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0G8AG
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| Former ID |
DNC006029
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| Drug Name |
BN-82685
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| Synonyms |
UNII-YLE5P531SS; BN-82685; YLE5P531SS; IRC-083065; SCHEMBL1917819; 4,7-Benzothiazoledione, 5-((2-(dimethylamino)ethyl)amino)-2-methyl-; 5-((2-(Dimethylamino)ethyl)amino)-2-methyl-1,3-benzothiazole-4,7-dione; 477603-18-2
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H15N3O2S
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| Canonical SMILES |
CC1=NC2=C(S1)C(=O)C=C(C2=O)NCCN(C)C
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| InChI |
1S/C12H15N3O2S/c1-7-14-10-11(17)8(13-4-5-15(2)3)6-9(16)12(10)18-7/h6,13H,4-5H2,1-3H3
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| InChIKey |
MTUYOFGUEXWKLC-UHFFFAOYSA-N
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| CAS Number |
CAS 477603-18-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | M-phase inducer phosphatase 3 (MPIP3) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Cell cycle | |||
| Oocyte meiosis | ||||
| Progesterone-mediated oocyte maturation | ||||
| MicroRNAs in cancer | ||||
| Panther Pathway | p53 pathway | |||
| Pathway Interaction Database | ATR signaling pathway | |||
| ATM pathway | ||||
| PLK1 signaling events | ||||
| PLK3 signaling events | ||||
| Reactome | Polo-like kinase mediated events | |||
| Cyclin B2 mediated events | ||||
| Activation of ATR in response to replication stress | ||||
| RHO GTPases activate PKNs | ||||
| Cyclin A/B1 associated events during G2/M transition | ||||
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | ||||
| WikiPathways | Monoamine Transport | |||
| DNA Damage Response | ||||
| ATM Signaling Pathway | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Mitotic G2-G2/M phases | ||||
| Cell Cycle | ||||
| Cell Cycle Checkpoints | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C. Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. | |||
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