Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0G7KJ
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| Former ID |
DAP001184
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| Drug Name |
Diflorasone
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| Synonyms |
Diflorasona; Diflorasonum; Maxiflor; Murode; U 34865; Diflorasona [INN-Spanish]; Diflorasone (INN); Diflorasone [INN:BAN]; Diflorasonum [INN-Latin]; Murode (TN); (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; (6alpha,11beta,16beta)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 6a,9a-difluoro-16b-methylprednisolone; 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
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| Drug Type |
Small molecular drug
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| Indication | Rosacea [ICD-11: ED90.0; ICD-10: L71.8, L71.9] | Approved | [1] | |
| Therapeutic Class |
Antiinflammatory Agents
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| Company |
Pharmacia And Upjohn Co
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| Structure |
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Download2D MOL |
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| Formula |
C22H28F2O5
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| Canonical SMILES |
CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F
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| InChI |
1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1
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| InChIKey |
WXURHACBFYSXBI-XHIJKXOTSA-N
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| CAS Number |
CAS 2557-49-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
855657, 7848390, 8194611, 11466647, 11467767, 11486513, 14761903, 24894203, 29215002, 43127743, 47365371, 47589149, 47736650, 48035306, 49699029, 50019411, 50103984, 56422226, 57318190, 57654135, 71840216, 76963292, 85787968, 92125524, 92720069, 99319112, 103770528, 103914477, 104350411, 117575834, 121363195, 124799710, 126620401, 131310944, 134338429, 135030323, 136135911, 137005254, 139836966, 144115906, 144204426, 160963571, 163134097, 163835798, 164822906, 170465294, 175268136, 175611936, 178103647, 179116650
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| ChEBI ID |
CHEBI:59750
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| ADReCS Drug ID | BADD_D00664 ; BADD_D00665 | |||
| SuperDrug ATC ID |
D07AC10
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| SuperDrug CAS ID |
cas=002557495
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -0.474; p = 0.025). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -0.475; p = 0.04). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -1.44; p = 0.011). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.636; p = 0.009). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.689; p = 0.004). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.636; p = 0.009). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.442; p = 0.025). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.469; p = 0.028). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -2.05; p = 0.003). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.677; p = 0.004). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -1.149; p = 0.004). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -1.045; p = 0.027). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -2.86; p = 0.002). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -1.837; p = 0.015). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -4.252; p = 0.015). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Odoribacter splanchnicus (log2FC = -0.558; p = 0.006). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.839; p = 0.006). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -0.987; p = 0.001). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -0.676; p = 0.015). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Pretovella copri DSM 18205 (log2FC = -6.55; p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.55; p = 0.004). | |||
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Studied Microbe: Clostridium sp.
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Clostridium sp. (log2FC = -0.511; p = 0.032). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Diflorasone diacetate can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -2.351; p = 0.003). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phospholipase A2 (PLA2G1B) | Target Info | Inhibitor | [3] |
| BioCyc | Phospholipases | |||
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Ether lipid metabolism | ||||
| Arachidonic acid metabolism | ||||
| Linoleic acid metabolism | ||||
| alpha-Linolenic acid metabolism | ||||
| Metabolic pathways | ||||
| Ras signaling pathway | ||||
| Vascular smooth muscle contraction | ||||
| Pancreatic secretion | ||||
| Fat digestion and absorption | ||||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
| Reactome | Acyl chain remodelling of PC | |||
| Acyl chain remodelling of PE | ||||
| Acyl chain remodelling of PI | ||||
| WikiPathways | Glycerophospholipid biosynthesis | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | Structures from powders: diflorasone diacetate. Steroids. 2009 Jan;74(1):102-11. | |||
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