Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0G4GB
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| Former ID |
DIB020604
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| Drug Name |
omega-chloroacetophenone
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| Synonyms |
mace (lacrimator); tear gas; phenacyl chloride; chloromethyl phenyl ketone
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C8H7ClO
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| Canonical SMILES |
C1=CC=C(C=C1)C(=O)CCl
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| InChI |
1S/C8H7ClO/c9-6-8(10)7-4-2-1-3-5-7/h1-5H,6H2
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| InChIKey |
IMACFCSSMIZSPP-UHFFFAOYSA-N
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| CAS Number |
CAS 532-27-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
96446, 3132350, 7776646, 8157790, 10525594, 11108627, 12078969, 15091111, 17389975, 24887196, 24892454, 26752938, 29229219, 48413428, 48421387, 48422357, 48424953, 49854413, 53787817, 57326443, 80183170, 88561139, 90341936, 99217986, 103321621, 104324182, 104749200, 117470385, 117470386, 117564255, 118307953, 124890596, 124890597, 124890598, 125308706, 125352338, 126553723, 126588922, 126612597, 126689020, 127275463, 127275464, 127275465, 127275466, 127275467, 127275468, 127275469, 127275470, 127275471, 127275472
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transformation-sensitive protein p120 (TRPA1) | Target Info | Activator | [2] |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | |||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6285). | |||
| REF 2 | Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol Appl Pharmacol. 2008 Sep 1;231(2):150-6. | |||
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