Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FY6Q
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| Former ID |
DIB009987
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| Drug Name |
JTK-109
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| Synonyms |
CHEMBL379677; 2-[4-(benzyloxy)phenyl]-1-cyclohexyl-1h-benzimidazole-5-carboxylic acid; AC1LAMB2; SCHEMBL791364; CTK7I8521; GWCTUYUNVJTNJR-UHFFFAOYSA-N; MolPort-039-347-685; BDBM50181950; ZINC28572342; AKOS027470656; 2-(4-benzyloxyphenyl)-1-cyclohexyl-benzimidazole-5-carboxylic acid; 1-cyclohexyl-2-(4-phenylmethoxyphenyl)benzimidazole-5-carboxylic acid; 2-(4-(benzyloxy)phenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylic acid; 1H-Benzimidazole-5-carboxylic acid, 1-cyclohexyl-2-[4-(phenylmethoxy)phenyl]-
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| Drug Type |
Small molecular drug
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| Indication | Hepatitis C virus infection [ICD-11: 1E51.1; ICD-10: B18.2] | Discontinued in Phase 1 | [1] | |
| Company |
Japan Tobacco Inc
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| Structure |
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Download2D MOL |
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| Formula |
C27H26N2O3
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| Canonical SMILES |
C1CCC(CC1)N2C3=C(C=C(C=C3)C(=O)O)N=C2C4=CC=C(C=C4)OCC5=CC=CC=C5
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| InChI |
1S/C27H26N2O3/c30-27(31)21-13-16-25-24(17-21)28-26(29(25)22-9-5-2-6-10-22)20-11-14-23(15-12-20)32-18-19-7-3-1-4-8-19/h1,3-4,7-8,11-17,22H,2,5-6,9-10,18H2,(H,30,31)
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| InChIKey |
GWCTUYUNVJTNJR-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018157) | |||
| REF 2 | Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109. J Med Chem. 2006 Jul 27;49(15):4721-36. | |||
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