Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FT8G
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| Drug Name |
PX-12
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| Synonyms |
PX12; PX 12; IV-2
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Pancreatic cancer [ICD-11: 2C10] | Phase 2 | [1] | |
| Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] | Investigative | [2] | ||
| Therapeutic Class |
Antiviral Agents
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| Company |
Biomira
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| Structure |
 |
Download2D MOL |
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| Formula |
C7H12N2S2
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| Canonical SMILES |
CCC(C)SSC1=NC=CN1
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| InChI |
1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
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| InChIKey |
BPBPYQWMFCTCNG-UHFFFAOYSA-N
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| CAS Number |
CAS 141400-58-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9374284, 15219811, 30422463, 57399846, 79245557, 103106749, 103564705, 113468605, 117402020, 123121574, 126460084, 135142363, 140114675, 162249061, 162310065, 162790932, 164154946, 164210775, 170364272, 174006855, 175427007, 177748841, 204361145, 210274949, 210280587, 215774935, 223392225, 223435396, 227058245, 243264143, 252156900, 252161718, 252475622
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| ChEBI ID |
CHEBI:94291
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | COVID-19 papain-like proteinase (PL-PRO) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A Randomized Phase II Study of PX-12, an Inhibitor of Thioredoxin in Patients With Advanced Cancer of the Pancreas Following Progression After a Gemcitabine-Containing Combination. Cancer Chemother Pharmacol. 2011 Mar;67(3):503-9. | |||
| REF 2 | Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9. | |||
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