Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FM9V
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| Drug Name |
PMID30107136-Compound-Example60
|
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| Drug Type |
Small molecule immunotherapy
|
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| Indication | Hepatitis [ICD-11: DB97.Z] | Patented | [1] | |
| Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 42] | Patented | [1] | ||
| Infectious disease [ICD-11: 1A00-CA43.1; ICD-10: A00-B99; ICD-9: 001-139] | Patented | [1] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
| Company |
RIJKSUNIVERSITEIT GRONINGEN
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H30N6O4
|
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| Canonical SMILES |
CC1=C(N(C(=N1)COC2=NC=CC(=C2C#N)C3=CC4=C(C=C3)OCCO4)CCO)CNCCNC
|
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| InChI |
1S/C25H30N6O4/c1-17-21(15-28-8-7-27-2)31(9-10-32)24(30-17)16-35-25-20(14-26)19(5-6-29-25)18-3-4-22-23(13-18)34-12-11-33-22/h3-6,13,27-28,32H,7-12,15-16H2,1-2H3
|
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| InChIKey |
WQHRKWCRQIAXRG-UHFFFAOYSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target Info | Inhibitor | [1] |
| Target's Patent Info | PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) | Target's Patent Info | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. | |||
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