Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FD9M
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| Former ID |
DIB019258
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| Drug Name |
PMID21536437C15c
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| Synonyms |
GTPL8553; BDBM50345537
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C26H38ClN3O5S
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| Canonical SMILES |
CC1=C(C=CC(=C1)Cl)CCC2CCN(CC2)S(=O)(=O)CC3(CCN(CC3)C(=O)C4CCC4)N(C=O)O
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| InChI |
1S/C26H38ClN3O5S/c1-20-17-24(27)8-7-22(20)6-5-21-9-13-29(14-10-21)36(34,35)18-26(30(33)19-31)11-15-28(16-12-26)25(32)23-3-2-4-23/h7-8,17,19,21,23,33H,2-6,9-16,18H2,1H3
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| InChIKey |
SIXCEPSXNLUZTE-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Aggrecanase (ADAMTS5) | Target Info | Inhibitor | [1] |
| Reactome | Degradation of the extracellular matrix | |||
| O-glycosylation of TSR domain-containing proteins | ||||
| WikiPathways | Endochondral Ossification | |||
| Vitamin D Receptor Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3301-6. | |||
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