Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FD2I
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| Former ID |
DIB004598
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| Drug Name |
Discodermolide
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| Synonyms |
Discodermolide, Novartis; XAA-296
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| Drug Type |
Small molecular drug
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| Indication | Immune System disease [ICD-11: 4A01-4B41; ICD-10: T86.0] | Discontinued in Phase 1 | [1] | |
| Company |
Harbor Branch Oceanographic Institute Inc
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| Structure |
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Download2D MOL |
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| Formula |
C33H55NO8
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| Canonical SMILES |
CC1C(OC(=O)C(C1O)C)CC(C=CC(C)C(C(C)C=C(C)CC(C)C(C(C)C(C(C)C=CC=C)OC(=O)N)O)O)O
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| InChI |
1S/C33H55NO8/c1-10-11-12-20(4)31(42-33(34)40)24(8)29(37)22(6)16-18(2)15-21(5)28(36)19(3)13-14-26(35)17-27-23(7)30(38)25(9)32(39)41-27/h10-15,19-31,35-38H,1,16-17H2,2-9H3,(H2,34,40)/b12-11-,14-13-,18-15-/t19-,20-,21-,22-,23-,24-,25+,26+,27-,28-,29+,30-,31-/m0/s1
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| InChIKey |
AADVCYNFEREWOS-OBRABYBLSA-N
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| CAS Number |
CAS 127943-53-7
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:80700
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tubulin (TUB) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008133) | |||
| REF 2 | The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, andinhibits the growth of paclitaxel-resistant cells. Mol Pharmacol. 1997 Oct;52(4):613-22. | |||
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