Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FC7L
|
|||
| Former ID |
DNC007117
|
|||
| Drug Name |
2-cyclohexylamino-pyridine-2-carbonitrile
|
|||
| Synonyms |
2-Cyano-pyridine, 8; 2-Pyridinecarbonitrile, 6-(cyclohexylamino)-; CHEMBL218522; BDBM19747; AKOS013783092; 927176-95-2
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C12H15N3
|
|||
| Canonical SMILES |
C1CCC(CC1)NC2=CC=CC(=N2)C#N
|
|||
| InChI |
1S/C12H15N3/c13-9-11-7-4-8-12(15-11)14-10-5-2-1-3-6-10/h4,7-8,10H,1-3,5-6H2,(H,14,15)
|
|||
| InChIKey |
IBXQOGXYFIMECI-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cathepsin K (CTSK) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Lysosome | |||
| Osteoclast differentiation | ||||
| Toll-like receptor signaling pathway | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| Trafficking and processing of endosomal TLR | ||||
| MHC class II antigen presentation | ||||
| WikiPathways | RANKL/RANK Signaling Pathway | |||
| Osteoclast Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.