Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FA5D
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| Drug Name |
Aromatic ring compound 3
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| Synonyms |
PMID25828189-Compound-43
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C29H28F6N4O3
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| Canonical SMILES |
CC1=C(C=CC(=C1)C2=NC=C(C=N2)C(F)(F)F)C(CCC(F)(F)F)NC3=CC=C(C=C3)C(=O)N4CCCC(C4)C(=O)O
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| InChI |
1S/C29H28F6N4O3/c1-17-13-19(25-36-14-21(15-37-25)29(33,34)35)6-9-23(17)24(10-11-28(30,31)32)38-22-7-4-18(5-8-22)26(40)39-12-2-3-20(16-39)27(41)42/h4-9,13-15,20,24,38H,2-3,10-12,16H2,1H3,(H,41,42)/t20-,24?/m1/s1
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| InChIKey |
HYBIWCXMSAEBQK-CGHJUBPDSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
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