Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F8QM
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| Former ID |
DIB016485
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| Drug Name |
FR-158999
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| Synonyms |
4-[4-(4-Amidinophenoxy)butyryl-L-aspartyl-L-valyl]thiomorpholine S,S-dioxide
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| Drug Type |
Small molecular drug
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| Indication | Thrombosis [ICD-11: DB61-GB90; ICD-10: I80-I82] | Discontinued in Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C24H35N5O8S
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| Canonical SMILES |
CC(C)C(C(=O)N1CCS(=O)(=O)CC1)NC(=O)C(CC(=O)O)NC(=O)CCCOC2=CC=C(C=C2)C(=N)N
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| InChI |
1S/C24H35N5O8S/c1-15(2)21(24(34)29-9-12-38(35,36)13-10-29)28-23(33)18(14-20(31)32)27-19(30)4-3-11-37-17-7-5-16(6-8-17)22(25)26/h5-8,15,18,21H,3-4,9-14H2,1-2H3,(H3,25,26)(H,27,30)(H,28,33)(H,31,32)/t18-,21-/m0/s1
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| InChIKey |
FPOQHPVEVPIFME-RXVVDRJESA-N
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| CAS Number |
CAS 160138-41-0
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011969) | |||
| REF 2 | QSAR study of the peptidic fibrinogen inhibitors FK633, FR158999 and related derivatives, using a novel and useful hydrophobic descriptor (logPmw). Bioorganic & Medicinal Chemistry Letters Volume 8, Issue 18, 22 September 1998, Pages 2483-2488. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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