Drug Information
Drug General Information | Top | |||
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Drug ID |
D0F7XM
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Former ID |
DIB018464
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Drug Name |
12-epi LTB4
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Synonyms |
12(S)-Leukotriene B4
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
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Download2D MOL
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Formula |
C20H32O4
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Canonical SMILES |
CCCCCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O
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InChI |
1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19+/m0/s1
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InChIKey |
VNYSSYRCGWBHLG-CBBLYLIKSA-N
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CAS Number |
CAS 83709-73-3
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:72795
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Target and Pathway | Top | |||
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Target(s) | Leukotriene B4 receptor 2 (LTB4R2) | Target Info | Agonist | [2] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
Reactome | Leukotriene receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | |||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6160). | |||
REF 2 | Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276(15):12454-9. |
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