Drug Information
Drug General Information | Top | |||
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Drug ID |
D0F7XJ
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Former ID |
DNC003615
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Drug Name |
2-Methoxyethyl 18-methoxycoronaridinate
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Synonyms |
CHEMBL607152; 2-Methoxyethyl 18-methoxycoronaridinate
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C24H32N2O4
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Canonical SMILES |
COCCC1CC2CC3(C1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OCCOC
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InChI |
1S/C24H32N2O4/c1-28-10-8-17-13-16-14-24(23(27)30-12-11-29-2)21-19(7-9-26(15-16)22(17)24)18-5-3-4-6-20(18)25-21/h3-6,16-17,22,25H,7-15H2,1-2H3/t16?,17-,22-,24+/m0/s1
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InChIKey |
OLFXZBDPKBSIPG-SAJNPJMVSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Neuronal acetylcholine receptor beta-4 (CHRNB4) | Target Info | Inhibitor | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Cholinergic synapse | ||||
Panther Pathway | Nicotinic acetylcholine receptor signaling pathway | |||
Nicotine pharmacodynamics pathway | ||||
Reactome | Highly sodium permeable acetylcholine nicotinic receptors | |||
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
Highly calcium permeable nicotinic acetylcholine receptors | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Nicotine Activity on Chromaffin Cells |
References | Top | |||
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REF 1 | Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003 Jun 19;46(13):2716-30. |
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