Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F7SO
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| Former ID |
DNC009044
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| Drug Name |
Quinoline-8-sulfonamide
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| Synonyms |
quinoline-8-sulfonamide; 8-Quinolinesulfonamide; 35203-91-9; 8-Sulfonamidoquinoline; Quinoline-8-sulfonic acid amide; CCRIS 7819; CHEMBL268809; SMR000009729; 8-quinoline-sulfonamide; 8-(Sulfamoyl)quinoline; AC1Q6ULO; AC1L3S9X; SCHEMBL50688; Oprea1_399346; Oprea1_819599; MLS001075858; MLS000070229; MLS001075623; CTK1C3889; DTXSID30188709; MolPort-000-398-364; ZTYZEUXZHGOXRT-UHFFFAOYSA-N; ZINC275697; HMS2220E20; HMS3356M20; ALBB-006579; NSC67458; STK387517; NSC-67458; 1294AE; BDBM50125190; AKOS000678636; MCULE-8159242011; BAS 00926056
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C9H8N2O2S
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| Canonical SMILES |
C1=CC2=C(C(=C1)S(=O)(=O)N)N=CC=C2
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| InChI |
1S/C9H8N2O2S/c10-14(12,13)8-5-1-3-7-4-2-6-11-9(7)8/h1-6H,(H2,10,12,13)
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| InChIKey |
ZTYZEUXZHGOXRT-UHFFFAOYSA-N
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| CAS Number |
CAS 35203-91-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Carbonic anhydrase II (CA-II) | Target Info | Inhibitor | [1] |
| Carbonic anhydrase IX (CA-IX) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Nitrogen metabolism | |||
| Proximal tubule bicarbonate reclamation | ||||
| Collecting duct acid secretion | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Bile secretion | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| EGFR1 Signaling Pathway | ||||
| Pathway Interaction Database | HIF-1-alpha transcription factor network | |||
| Reactome | Regulation of gene expression by Hypoxia-inducible Factor | |||
| Reversible hydration of carbon dioxide | ||||
| Erythrocytes take up carbon dioxide and release oxygen | ||||
| Erythrocytes take up oxygen and release carbon dioxide | ||||
| WikiPathways | Vitamin D Receptor Pathway | |||
| Reversible Hydration of Carbon Dioxide | ||||
| Regulation of Hypoxia-inducible Factor (HIF) by Oxygen | ||||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | ||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. Bioorg Med Chem. 2009 Jan 15;17(2):553-7. | |||
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