Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F6EO
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| Former ID |
DAP000443
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| Drug Name |
Amoxicillin
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| Synonyms |
AMPC; Actimoxi; Amoclen; Amolin; Amopen; Amopenixin; Amoxi; Amoxibiotic; Amoxicaps; Amoxicilina; Amoxicillanyl; Amoxicilline; Amoxicillinum; Amoxiden; Amoxil; Amoxivet; Amoxycillin; Anemolin; Aspenil; Biomox; Bristamox; Cemoxin; Clamoxyl; Delacillin; DisperMox; Efpenix; Flemoxin; Hiconcil; Histocillin; Hydroxyampicillin; Ibiamox; Imacillin; Lamoxy; Larotid; Moxacin; Moxal; Moxatag; Ospamox; Pamoxicillin; Piramox; Polymox; Robamox; Sumox; Tolodina; Trimox; Unicillin; Utimox; Vetramox; Wymox; AMOXICILLIN CRYSTALLINE; AMOXICILLIN PEDIATRIC; Amoxicillin anhydrous; Amoxicilline [INN]; Amoxycillin Trihydrate; Metafarma capsules; Metifarma capsules; Sawamox PM; BLP 1410; AMK (TN); Actimoxi (TN); Alphamox (TN); Amoksibos (TN); Amoksiklav (TN); Amoxi-Mast; Amoxibiotic (TN); Amoxicilina (TN); Amoxicilina [INN-Spanish]; Amoxicillin (INN); Amoxicillin (TN); Amoxicillin (anhydrous); Amoxicilline [INN-French]; Amoxicillinum [INN-Latin]; Amoxiclav (TN); Amoxidal (TN); Amoxil (TN); Amoxin (TN); Apo-Amoxi; Augmentin (TN); BL-P 1410; BRL-2333; Bactox (TN); Betalaktam (TN); Cilamox (TN); Clamoxyl (TN); Curam (TN); D-Amoxicillin; Dedoxil (TN); Dispermox (TN); Duomox (TN); Enhancin (TN); Geramox (TN); Gimalxina (TN); Hiconcil (TN); Isimoxin (TN); Klavox (TN); Lamoxy (TN); Moxatag (TN); Moxilen (TN); Moxypen (TN); Moxyvit (TN); Nobactam (TN); Novamoxin (TN); Ospamox (TN); P-Hydroxyampicillin; Pamoxicillin (TN); Panamox (TN); Panklav (TN); Polymox (TN); Ro 10-8756; Samthongcillin (TN); Sandoz (TN); Senox (TN); Sinacilin (TN); Tolodina (TN); Trimox (TN); Wymox (TN); Yucla (TN); Zerrsox (TN); Zimox (TN); Apo-Amoxi (TN); Alpha-Amino-p-hydroxybenzylpenicillin; D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid; D-(-)-alpha-Amino-p-hydroxybenzylpenicillin; (-)-6-(2-Amino-2-(P-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo-(3.2.0)heptane-2-carboxylic acid; (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-(p-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-, D-(8CI); 6-(D-(-)-alpha-Amino-p-hydroxyphenylacetamido)penicillanic acid; 6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin; 6-(p-Hydroxy-alpha-aminophenylacetamido)penicillanic acid; 6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carbonyl; 6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [1] | |
| Therapeutic Class |
Antibiotics
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| Company |
AstraZeneca
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H19N3O5S
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| Canonical SMILES |
CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
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| InChI |
1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1
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| InChIKey |
LSQZJLSUYDQPKJ-NJBDSQKTSA-N
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| CAS Number |
CAS 26787-78-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9045, 625395, 855939, 7978697, 8173210, 10321668, 11466385, 11467505, 11486110, 14803689, 14852747, 34675405, 46507578, 47277019, 47500930, 48020429, 48244812, 49698452, 50050650, 50124271, 51091783, 56310905, 56312972, 56464141, 57288747, 57311544, 75691305, 85148361, 85787504, 92125419, 92711519, 96099939, 103296891, 103914155, 104170168, 104178892, 104316487, 119525230, 121362635, 121363090, 124766400, 124799877, 126630772, 126657267, 134337739, 134997708, 135769296, 136357150, 137002906, 139157548
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| ChEBI ID |
CHEBI:2676
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| ADReCS Drug ID | BADD_D00129 | |||
| SuperDrug ATC ID |
J01CA04
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| SuperDrug CAS ID |
cas=026787780
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Agaricales | ||||
|
Studied Microbe: Morganella
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Morganella was increased by Amoxicillin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacillales | ||||
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Studied Microbe: Bacillus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bacillus was not significantly changed by Amoxicillin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Alistipes was increased by Amoxicillin. | |||
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Studied Microbe: Bacteroides
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bacteroides was increased by Amoxicillin. | |||
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Studied Microbe: Bacteroides
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[2] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Bacteroides was not significantly changed by Amoxicillin. | |||
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Studied Microbe: Bacteroides caccae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Amoxicillin (adjusted p-values: 9.41E-06). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Amoxicillin (adjusted p-values: 4.58E-03). | |||
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Studied Microbe: Bacteroides ovatus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Amoxicillin (adjusted p-values: 9.22E-03). | |||
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Studied Microbe: Bacteroides uniformis
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Amoxicillin (adjusted p-values: 5.21E-03). | |||
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Studied Microbe: Bacteroides vulgatus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Amoxicillin (adjusted p-values: 4.84E-06). | |||
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Studied Microbe: Odoribacter splanchnicus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Amoxicillin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Parabacteroides
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|
[6] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Parabacteroides was increased by Combination of amoxicillin and clavulanate. | |||
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Studied Microbe: Parabacteroides
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Parabacteroides was increased by Amoxicillin. | |||
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Studied Microbe: Parabacteroides distasonis
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Amoxicillin (adjusted p-values: 8.54E-06). | |||
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Studied Microbe: Parabacteroides merdae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Amoxicillin (adjusted p-values: 4.93E-07). | |||
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Studied Microbe: Prevotella copri
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Amoxicillin (adjusted p-values: 1.02E-04). | |||
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Studied Microbe: Prevotellaceae
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|
[7] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Prevotellaceae was decreased by Amoxicillin. | |||
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Studied Microbe: Rikenellaceae
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|
[7] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Rikenellaceae was decreased by Amoxicillin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium
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|
[8] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bifidobacterium was decreased by Combination of amoxicillin and clavulanate. | |||
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Studied Microbe: Bifidobacterium
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bifidobacterium was decreased by Amoxicillin. | |||
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Studied Microbe: Bifidobacterium
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[2] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Bifidobacterium was not significantly changed by Amoxicillin. | |||
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Studied Microbe: Bifidobacterium adolescentis
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium adolescentis was decreased by Amoxicillin (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bifidobacterium longum
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium longum was decreased by Amoxicillin (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Burkholderiales | ||||
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Studied Microbe: Comamonadaceae
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|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Comamonadaceae was increased by Amoxicillin (p = 0.024). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Chitinophagales | ||||
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Studied Microbe: Chitinophagaceae
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|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Chitinophagaceae was increased by Amoxicillin (p = 0.024). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Collinsella was decreased by Amoxicillin. | |||
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Studied Microbe: Collinsella aerofaciens
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Amoxicillin (adjusted p-values: 2.74E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Cytophagales | ||||
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Studied Microbe: Cytophagaceae
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|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Cytophagaceae was increased by Amoxicillin (p = 0.011). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Amoxicillin (adjusted p-values: 1.10E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Citrobacter
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|
[10] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Citrobacter was increased by Combination of omeprazole, amoxicillin and metronidazole. | |||
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Studied Microbe: Citrobacter
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Citrobacter was increased by Amoxicillin. | |||
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Studied Microbe: Enterobacter
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterobacter was increased by Combination of amoxicillin and clavulanate. | |||
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Studied Microbe: Enterobacter
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Enterobacter was increased by Amoxicillin. | |||
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Studied Microbe: Enterobacter
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Enterobacter was increased by Amoxicillin (p = 0.003). | |||
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Studied Microbe: Enterobacter
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Enterobacter was increased by Amoxicillin (p = 0.003). | |||
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Studied Microbe: Enterobacteriaceae
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[11] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterobacteriaceae was increased by Combination of amoxicillin and clavulanate. | |||
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Studied Microbe: Enterobacteriaceae
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|
[10] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Enterobacteriaceae was increased by Combination of omeprazole, amoxicillin and metronidazole. | |||
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Studied Microbe: Enterobacteriaceae
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Enterobacteriaceae was increased by Amoxicillin. | |||
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Studied Microbe: Enterobacteriaceae
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|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Enterobacteriaceae was increased by Amoxicillin (p = 0.001). | |||
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Studied Microbe: Enterobacteriaceae
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|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Enterobacteriaceae was increased by Amoxicillin (p = 0.001). | |||
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Studied Microbe: Escherichia
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Escherichia was increased by Combination of amoxicillin and clavulanate. | |||
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Studied Microbe: Escherichia
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Escherichia was decreased by Amoxicillin. | |||
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Studied Microbe: Escherichia coli ED1a
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Escherichia coli ED1a was decreased by Amoxicillin (adjusted p-values: 1.58E-05). | |||
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Studied Microbe: Escherichia coli IAI1
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Escherichia coli IAI1 was decreased by Amoxicillin (adjusted p-values: 1.05E-06). | |||
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Studied Microbe: Escherichia/Shigella
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[12] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Escherichia/Shigella was increased by Amoxicillin. | |||
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Studied Microbe: Klebsiella
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[11] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Klebsiella was increased by Combination of amoxicillin and clavulanate. | |||
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Studied Microbe: Klebsiella
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|
[10] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Klebsiella was increased by Combination of omeprazole, amoxicillin and metronidazole. | |||
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Studied Microbe: Klebsiella
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Klebsiella was increased by Amoxicillin. | |||
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Studied Microbe: Shigella
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Shigella was increased by Amoxicillin (p = 0.001). | |||
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Studied Microbe: Shigella
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Shigella was increased by Amoxicillin (p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Catenibacterium
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Catenibacterium was decreased by Combination of amoxicillin and clavulanate. | |||
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Studied Microbe: Erysipelatoclostridium ramosum
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Amoxicillin (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Blautia was decreased by Amoxicillin. | |||
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Studied Microbe: Blautia obeum
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Amoxicillin (adjusted p-values: 9.60E-07). | |||
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Studied Microbe: Clostridiaceae
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Clostridiaceae was decreased by Amoxicillin (p = 0.009). | |||
|
Studied Microbe: Clostridiaceae
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Clostridiaceae was decreased by Amoxicillin (p = 0.009). | |||
|
Studied Microbe: Clostridioides difficile
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridioides difficile was decreased by Amoxicillin (adjusted p-values: 5.86E-06). | |||
|
Studied Microbe: Clostridium
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|
[3], [13] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Clostridium was decreased by Amoxicillin. | |||
|
Studied Microbe: Clostridium
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|
[14] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Clostridium was increased by Amoxicillin. | |||
|
Studied Microbe: Clostridium
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|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Clostridium was decreased by Amoxicillin (p = 0.019). | |||
|
Studied Microbe: Clostridium
Show/Hide Hierarchy
|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Clostridium was decreased by Amoxicillin (p = 0.019). | |||
|
Studied Microbe: Clostridium perfringens
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Amoxicillin (adjusted p-values: 5.51E-07). | |||
|
Studied Microbe: Coprococcus
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Coprococcus was increased by Combination of amoxicillin and clavulanate. | |||
|
Studied Microbe: Coprococcus
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Coprococcus was decreased by Amoxicillin. | |||
|
Studied Microbe: Coprococcus comes
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Amoxicillin (adjusted p-values: 5.04E-06). | |||
|
Studied Microbe: Dorea
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Dorea was decreased by Amoxicillin. | |||
|
Studied Microbe: Dorea formicigenerans
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Amoxicillin (adjusted p-values: 5.04E-06). | |||
|
Studied Microbe: Enterocloster bolteae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Amoxicillin (adjusted p-values: 4.98E-03). | |||
|
Studied Microbe: Eubacterium eligens
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Amoxicillin (adjusted p-values: 1.07E-05). | |||
|
Studied Microbe: Eubacterium rectale
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Amoxicillin (adjusted p-values: 3.87E-04). | |||
|
Studied Microbe: Faecalibacterium
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[12] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Faecalibacterium was decreased by Amoxicillin. | |||
|
Studied Microbe: Lachnospiraceae
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Lachnospiraceae was decreased by Amoxicillin. | |||
|
Studied Microbe: Lacrimispora saccharolytica
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Amoxicillin (adjusted p-values: 5.51E-07). | |||
|
Studied Microbe: Peptostreptococcus
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|
[10] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Peptostreptococcus was increased by Combination of omeprazole, amoxicillin and metronidazole. | |||
|
Studied Microbe: Roseburia
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Roseburia was decreased by Combination of amoxicillin and clavulanate. | |||
|
Studied Microbe: Roseburia
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Roseburia was decreased by Amoxicillin. | |||
|
Studied Microbe: Roseburia hominis
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Amoxicillin (adjusted p-values: 3.72E-05). | |||
|
Studied Microbe: Roseburia intestinalis
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Amoxicillin (adjusted p-values: 2.54E-04). | |||
|
Studied Microbe: Ruminococcus
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|
[8] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Ruminococcus was not significantly changed by Combination of amoxicillin and clavulanate. | |||
|
Studied Microbe: Ruminococcus
Show/Hide Hierarchy
|
[14] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Ruminococcus was increased by Amoxicillin. | |||
|
Studied Microbe: Ruminococcus bromii
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Amoxicillin (adjusted p-values: 1.99E-05). | |||
|
Studied Microbe: Ruminococcus gnavus
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Amoxicillin (adjusted p-values: 5.04E-06). | |||
|
Studied Microbe: Ruminococcus torques
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Amoxicillin (adjusted p-values: 6.63E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Hyphomicrobiales | ||||
|
Studied Microbe: Methylobacteriaceae
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|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Methylobacteriaceae was increased by Amoxicillin (p = 0.013). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
|
Studied Microbe: Enterococcus
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|
[15] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterococcus was increased by Combination of amoxicillin and clavulanate. | |||
|
Studied Microbe: Enterococcus
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|
[10] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Enterococcus was increased by Combination of omeprazole, amoxicillin and metronidazole. | |||
|
Studied Microbe: Enterococcus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Enterococcus was increased by Amoxicillin. | |||
|
Studied Microbe: Lactobacillaceae
Show/Hide Hierarchy
|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Lactobacillaceae was decreased by Amoxicillin (p = 0.004). | |||
|
Studied Microbe: Lactobacillaceae
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|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Lactobacillaceae was decreased by Amoxicillin (p = 0.004). | |||
|
Studied Microbe: Lactobacillus
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|
[15] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Lactobacillus was decreased by Combination of amoxicillin and clavulanate. | |||
|
Studied Microbe: Lactobacillus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Lactobacillus was not significantly changed by Amoxicillin. | |||
|
Studied Microbe: Lactobacillus
Show/Hide Hierarchy
|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Lactobacillus was decreased by Amoxicillin (p = 0.004). | |||
|
Studied Microbe: Lactobacillus
Show/Hide Hierarchy
|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Lactobacillus was decreased by Amoxicillin (p = 0.004). | |||
|
Studied Microbe: Lactobacillus paracasei
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lactobacillus paracasei was decreased by Amoxicillin (adjusted p-values: 7.83E-07). | |||
|
Studied Microbe: Streptococcus parasanguinis
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus parasanguinis was decreased by Amoxicillin (adjusted p-values: 1.67E-06). | |||
|
Studied Microbe: Streptococcus salivarius
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Amoxicillin (adjusted p-values: 6.54E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Moraxellales | ||||
|
Studied Microbe: Moraxellaceae
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|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Moraxellaceae was increased by Amoxicillin (p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Mycobacteriales | ||||
|
Studied Microbe: Corynebacterium
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Corynebacterium was decreased by Amoxicillin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Parachlamydiales | ||||
|
Studied Microbe: Rhabdochlamydiaceae
Show/Hide Hierarchy
|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Rhabdochlamydiaceae was increased by Amoxicillin (p = 0.042). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
|
Studied Microbe: Dialister
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Dialister was decreased by Amoxicillin. | |||
|
Studied Microbe: Veillonella
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Helicobacter pylori infection | |||
| Description | The abundance of Veillonella was decreased by Amoxicillin. | |||
|
Studied Microbe: Veillonella parvula
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Veillonella parvula was decreased by Amoxicillin (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
|
Studied Microbe: Akkermansia
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Akkermansia was not significantly changed by Amoxicillin. | |||
|
Studied Microbe: Akkermansia muciniphila
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Akkermansia muciniphila was decreased by Amoxicillin (adjusted p-values: 2.71E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
|
Studied Microbe: Bacteroidales
Show/Hide Hierarchy
|
[7] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bacteroidales was decreased by Amoxicillin. | |||
|
Studied Microbe: Bacteroidetes
Show/Hide Hierarchy
|
[7] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bacteroidetes was decreased by Amoxicillin. | |||
|
Studied Microbe: Burkholderiales
Show/Hide Hierarchy
|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Burkholderiales was increased by Amoxicillin (p = 0.01). | |||
|
Studied Microbe: Firmicutes
Show/Hide Hierarchy
|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Firmicutes was decreased by Amoxicillin. | |||
|
Studied Microbe: Firmicutes
Show/Hide Hierarchy
|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Firmicutes was decreased by Amoxicillin. | |||
|
Studied Microbe: Proteobacteria
Show/Hide Hierarchy
|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Proteobacteria was increased by Amoxicillin. | |||
|
Studied Microbe: Proteobacteria
Show/Hide Hierarchy
|
[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Proteobacteria was increased by Amoxicillin. | |||
| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Cell membrane (Bact CM) | Target Info | Modulator | [16] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging therapies for the treatment and prevention of otitis media. Expert Opin Emerg Drugs. 2006 May;11(2):251-64. | |||
| REF 2 | Effects of omeprazole and amoxycillin on the human oral and gastrointestinal microflora in patients with Helicobacter pylori infection. J Antimicrob Chemother. 1996 Dec;38(6):927-39. | |||
| REF 3 | Effect of lactic acid producing bacteria on the human intestinal microflora during ampicillin treatment. Scand J Infect Dis. 1991;23(2):247-54. | |||
| REF 4 | Same Exposure but Two Radically Different Responses to Antibiotics: Resilience of the Salivary Microbiome versus Long-Term Microbial Shifts in Feces. mBio. 2015 Nov 10;6(6):e01693-15. | |||
| REF 5 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 6 | Prospective randomized controlled study on the effects of Saccharomyces boulardii CNCM I-745 and amoxicillin-clavulanate or the combination on the gut microbiota of healthy volunteers. Gut Microbes. 2017 Jan 2;8(1):17-32. | |||
| REF 7 | Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. Nat Commun. 2015 Jun 30;6:7486. | |||
| REF 8 | Long-term changes in human colonic Bifidobacterium populations induced by a 5-day oral amoxicillin-clavulanic acid treatment. PLoS One. 2012;7(11):e50257. | |||
| REF 9 | Metagenomic Analysis of Antibiotic-Induced Changes in Gut Microbiota in a Pregnant Rat Model. Front Pharmacol. 2016 Apr 28;7:104. | |||
| REF 10 | Comparative effects of omeprazole, amoxycillin plus metronidazole versus omeprazole, clarithromycin plus metronidazole on the oral, gastric and intestinal microflora in Helicobacter pylori-infected patients. J Antimicrob Chemother. 1999 Nov;44(5):629-40. | |||
| REF 11 | The influence of flucloxacillin and amoxicillin with clavulanic acid on the aerobic flora of the alimentary tract. Infection. 1987 Jul-Aug;15(4):241-4. | |||
| REF 12 | Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial. Gut Microbes. 2014 Jul 1;5(4):458-67. | |||
| REF 13 | Impact of cefpodoxime proxetil and amoxicillin on the normal oral and intestinal microflora. Eur J Clin Microbiol Infect Dis. 1993 Sep;12(9):714-9. | |||
| REF 14 | Resilience of the dominant human fecal microbiota upon short-course antibiotic challenge. J Clin Microbiol. 2005 Nov;43(11):5588-92. | |||
| REF 15 | Ecological effects of linezolid versus amoxicillin/clavulanic acid on the normal intestinal microflora. Scand J Infect Dis. 2001;33(12):899-903. | |||
| REF 16 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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