Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F1ZB
|
|||
| Former ID |
DIB008226
|
|||
| Drug Name |
LFA-102
|
|||
| Drug Type |
Antibody
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1] | |
| Company |
Novartis AG
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prolactin receptor (PRLR) | Target Info | . | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Neuroactive ligand-receptor interaction | ||||
| PI3K-Akt signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Prolactin signaling pathway | ||||
| Pathway Interaction Database | ErbB4 signaling events | |||
| Signaling events mediated by PTP1B | ||||
| Reactome | Prolactin receptor signaling | |||
| Growth hormone receptor signaling | ||||
| WikiPathways | Ovarian Infertility Genes | |||
| Prolactin receptor signaling | ||||
| Growth hormone receptor signaling | ||||
| Adipogenesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01610050) A Phase I Study of LFA102 in Japanese Patients. U.S. National Institutes of Health. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1721). | |||
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